THE ROLE OF HEMATOLOGICAL PARAMETERS IN IDENTIFYING MODERATE FROM SEVERE COVID-19 CASES
Keywords:
COVID-19, Neutrophil-to-Lymphocyte Ratio, hematological parameters, severityAbstract
Background: As severe cases of Coronavirus disease 2019 (COVID-19) may deteriorate rapidly and develop acute respiratory distress syndrome so finding simple useful indicators to predict the severity of the disease is very helpful in its management.Methods :We collected some personal and hematology data from 108 patients with COVID-19 infection for retrospective analysis. The cases were divided into two groups; severe and moderate .Results: The differences of white blood cells and platelets between the two groups were non-significant (P >0.05). On the other hand, the differences between the two groups regarding lymphocyte count and percentage, neutrophils count and percentage, hemoglobin concentration, red blood cells , neutrophil-to-lymphocyte ratio (NLR) were significant, (P<0.05). It was obvious that neutrophils percentage was the most accurate studied parameter in predicting the severity of COVID-19 infection (The area under the curve (AUC), cut-off, sensitivity and specificity were 0.732, 80.15%, 78%, 70.1% respectively.), followed by NLR ( The AUC, cut-off, sensitivity and specificity were 0.725, 5.75, 75.6%, 62.7% respectively).Conclusion: several hematological parameters can help in early detection of the severity of the COVID-19 infection. The widest AUC was of neutrophil percentage followed by that of NLR.
References
Chen G, Wu DI, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, Zhang X. Clinical and immunological features of severe and moderate coronavirus disease 2019. The Journal of clinical investigation. 2020 May 1;130(5):2620-9.
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G. First case of 2019 novel coronavirus in the United States. New England Journal of Medicine. 2020 Jan 31.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Yu T. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama. 2020 Mar 17;323(11):1061-9.
Yun H, Sun Z, Wu J, Tang A, Hu M, Xiang Z. Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients. Clinica Chimica Acta. 2020 Aug 1;507:94-7.
Liu J, Liu Y, Xiang P, Pu L, Xiong H, Li C, Zhang M, Tan J, Xu Y, Song R, Song M. Neutrophil-to-lymphocyte ratio predicts severe illness patients with 2019 novel coronavirus in the early stage. MedRxiv. 2020 Jan 1.
Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, Wang G, Fu W, Xiao J, Ding X, Li T. Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Annals of translational medicine. 2020 May;8(9).
Dong YM, Sun J, Li YX, Chen Q, Liu QQ, Sun Z, Pang R, Chen F, Xu BY, Manyande A, Clark TG. Development and validation of a nomogram for assessing survival in patients with COVID-19 pneumonia. Clinical Infectious Diseases. 2021 Feb 15;72(4):652-60.
Fei M, Tong F, Tao X, Wang J. Value of neutrophil-to-lymphocyte ratio in the classification diagnosis of coronavirus disease 2019. Zhonghua wei zhong bing ji jiu yi xue. 2020 May 1;32(5):554-8.
Zhang H, Cao X, Kong M, Mao X, Huang L, He P, Pan S, Li J, Lu Z. Clinical and hematological characteristics of 88 patients with COVID‐19. International journal of laboratory hematology. 2020 Dec;42(6):780-7.
Ozbalak M, Besisik SK, Tor YB, Medetalibeyoglu A, Kose M, Senkal N, Aksoy E, Cagatay A, Erelel M, Gul A, Esen F. Initial complete blood count score and predicting disease progression in COVID-19 patients. American journal of blood research. 2021;11(1):77.
Usul E, Şan İ, Bekgöz B, Şahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomarkers in Medicine. 2020 Sep;14(13):1207-15.
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