THE PREVALENCE OF ANTI-HBC ANTIBODY AMONG HBS AG-NEGATIVE LIBYAN BLOOD DONORS AND ITS ASSOCIATION WITH HBV DNA IN THE SERUM
Keywords:
HBV infection, anti-HBc, HBV-DNA, blood donors, LibyaAbstract
A hundred blood donors with hepatitis B surface antigen (HBs Ag) negative serology were enrolled in our study. These blood donors were investigated for the presence of antibodies to HBV core antigen (anti-HBc). Positive anti-HBc samples were further screened for anti-HBs antibodies, and for hepatitis B virus (HBV) DNA by real time Polymerase Chain Reaction technique.
Results: The donors found to be Anti-HBc positive were 14 (represent 14% of all donors), among them 11 were positive for both Anti-HBcantibodies and anti-HBs antibodies, while three donors were positive for Anti-HBc antibodiesalone. All Anti-HBc positive samples were investigated by Polymerase Chain Reaction technique and found to be negative for HBV-DNA (which it might be attributed to low sensitivity of the used Polymerase Chain Reaction technique). Despite that, it would be much safer to introduce anti-HBc screening for blood donors and discard all blood units which are positive for anti-HBc alone
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