OCCULT HBV INFECTION IN HIV-INFECTED LIBYAN PATIENTS WITH POSITIVE ANTI-HBc
Keywords:
HBV, HIV, Isolated anti-HBc, OBIAbstract
Occult hepatitis B infection (OBI) is common among human immunodeficiency virus (HIV) cases. Co-infection with HIV may worsen HBV infection. We aimed to determine the OBI prevalence in positive hepatitis B core antigen antibody ( anti-HBc ) HIV-infected patients. One hundred forty one hepatitis B surface antigen ( HBsAg ) negative Libyan HIV cases were tested for CD4 T cell count and anti-HBc. Positive anti-HBc samples were evaluated for hepatitis B surface antigen antibody (anti-HBs) and HBV DNA by real-time polymerase chain reaction (PCR). Positive anti-HBc was detected in 82/141 (58.2%) of the studied cases. Isolated anti-HBc was found in 36/141 cases (25.5%) . OBI was detected in 9/82 (11%) cases out of anti-HBc positive cases. Five (55.6%) of them was associated with isolated anti-HBc. CD4 T cell count was lower than 350 cells/mm3 in all OBI cases (p = 0.001). We concluded that OBI is common in Libyan HIV patients with positive anti-HBc and a larger study to find the prevalence of OBI in HIV-infected cases would be of advantage
References
C. Holtkamp, M. Fiedler, U. Dittmer, and O. E. Anastasiou, "The Course of Anti-HBc Antibodies over Time in Immunocompromised Hosts," Vaccines, vol. 10, no. 2, p. 137, 2022.
D. Fopa, D. Candotti, C.T. Tagny, C. Doux, D. Mbanya, E.L. Murphy, H.I. Kenawy, F. El Chenawi, S. Laperche, "Occult hepatitis B infection among blood donors from Yaoundé, Cameroon," Blood Transfusion, vol. 17, no. 6, p. 403, 2019.
M. A. Daw, A. Shabash, A. El-Bouzedi, A. A. Dau, In association with the Libyan Study Group of Hepatitis & HIV, "Seroprevalence of HBV, HCV & HIV co-infection and risk factors analysis in Tripoli-Libya," PloS one, vol. 9, no. 6, p. e98793, 2014.
G. Gachara, T. Magoro, L. Mavhandu, E. Lum, H.K. Kimbi, R.N. Ndip, P.O. Bessong, "Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon," (in eng), AIDS Res Ther, vol. 14, no. 1, p. 11, Mar 8 2017, doi: 10.1186/s12981-017-0136-0.
O. O. Opaleye, A.S. Oluremi, A.B. Atiba, M.O. Adewumi, O.V. Mabayoje, E. Donbraye, O. Ojurongbe, O.A. Olowe, "Occult hepatitis B virus infection among HIV positive patients in Nigeria," Journal of tropical medicine, vol. 2014, 2014.
J. J. Chang, N. Mohtashemi, and D. Bhattacharya, "Significance and Management of Isolated Hepatitis B Core Antibody (Anti-HBc) in HIV and HCV: Strategies in the DAA Era," (in eng), Curr HIV/AIDS Rep, vol. 15, no. 2, pp. 172-181, Apr 2018, doi: 10.1007/s11904-018-0379-y.
F. Azmoudeh-Ardalan and M. Khodabandehloo, "Prevalence of overt and occult hepatitis b virus infection among hiv-positive people referring to consultation center for behavioral diseases, kurdistan province, iran," Iranian Biomedical Journal, vol. 25, no. 6, p. 434, 2021.
C. Saitta, T. Pollicino, and G. Raimondo, "Occult hepatitis B virus infection: an update," Viruses, vol. 14, no. 7, p. 1504, 2022.
A. Salyani, J. Shah, R. Adam, G. Otieno, E. Mbugua, and R. Shah, "Occult hepatitis B virus infection in a Kenyan cohort of HIV infected anti-retroviral therapy naïve adults," PLoS One, vol. 16, no. 1, p. e0244947, 2021.
M. C. Kuhns, V. Holzmayer, M. Anderson, A.L. McNamara, S. Sauleda, D. Mbanya, P.T. Duong, N.T. Dung, G.A. Cloherty, "Molecular and serological characterization of hepatitis B virus (HBV)-positive samples with very low or undetectable levels of HBV surface antigen," Viruses, vol. 13, no. 10, p. 2053, 2021.
B. Doro, W.M. Zawia, W.M. Husien, N.M. Abdalla, A.M. Rifai, E. Dourou, F.J. Amar, A.N. Aboughress, "Blood donors status of HIV, HBV and HCV in Central Blood Bank in Tripoli, Libya," International Blood Research & Reviews, vol. 4, no. 3, pp. 1-8, 2015.
D. A. Ayana, A. Mulu, A. Mihret, B. Seyoum, A. Aseffa, and R. Howe, "Occult Hepatitis B virus infection among HIV negative and positive isolated anti-HBc individuals in eastern Ethiopia," Scientific reports, vol. 10, no. 1, p. 22182, 2020.
R. Panigrahi, S. Majumder, M. Gooptu, A. Biswas, S. Datta, P.K. Chandra, A. Banerjee, S. Chakrabarti, D. Bandopadhyay, B.K. De, R. Chakravarty, "Occult HBV infection among anti-HBc positive HIV-infected patients in apex referral centre, Eastern India," Annals of hepatology, vol. 11, no. 6, pp. 870-875, 2012.
N. F. Abdelaziz, M. M. Fekry, and M. H. Hashish, "Occult Hepatitis B Virus Infection in Egyptian HIV-Infected Patients with Isolated Anti-HBc," Journal of High Institute of Public Health, vol. 49, no. 3, pp. 162-167, 2019, doi: 10.21608/jhiph.2019.59201.
D. Saha, A. Pal, N. Sarkar, D. Das, J.T. Blackard, S.K. Guha, B. Saha, R. Chakravarty, "Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India," PLoS One, vol. 12, no. 6, p. e0179035, 2017.
A. Honarmand, M. Pourahmad, K. Solhjoo, M. Kohan, M. H. Davami, and S. K. Zadeh, "Occult hepatitis B demonstrated by anti-HBc and HBV DNA in HIV-positive patients," Reports of biochemistry & molecular biology, vol. 3, no. 1, p. 38, 2014.
N. H. Patel, V. Meier-Stephenson, M. Genetu, D. Damtie, E. Abate, S. Alemu, Y. Aleka, G. Van Marle, K. Fonseca, C.S. Coffin, T. Deressa,"Prevalence and genetic variability of occult hepatitis B virus in a human immunodeficiency virus positive patient cohort in Gondar, Ethiopia," PLoS One, vol. 15, no. 11, p. e0242577, 2020.
A.M. Albakosh, F.O. Alshwin, T.M. Arshah. "The prevalence of anti-HBc antibody among HBsAg-negative Libyan blood donors and its association with HBV DNA in the serum," Journal of basic sciences, vol. 30;30, pp. 76-82, 2017 Jun
A. A. Carimo, E.S. Gudo, C. Maueia , N. Mabunda, L. Chambal, A. Vubil, A. Flora , F. Antunes , N. Bhatt. "First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique," PloS one, vol. 13, no. 1, p. e0190775, 2018.
S. Gupta and S. Singh, "Occult hepatitis B virus infection in ART-naive HIV-infected patients seen at a tertiary care centre in north India," BMC infectious diseases, vol. 10, pp. 1-7, 2010.
A. Ramezani, M.R. Aghasadeghi, F. Ahmadi, E. Razeghi, A. Eslamifar, M. Banifazl, M. Sofian, G. Bahramali, S. Hekmat, A. Aghakhani,"Isolated anti-hbc and occult HBV infection in dialysis patients," Nephro-urology monthly, vol. 7, no. 1, 2015.
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