الخلايا الجذعية الوسيطة واستخدامها في مرض التهاب الأمعاء

المؤلفون

  • نور الأمل الأشهب قسم علم الحيوان، كلية العوم، الجامعة الاسمرية الإسلامية، زليتن – ليبيا
  • خولة ناجي والي قسم علم الحيوان، كلية العوم، الجامعة الاسمرية الإسلامية، زليتن – ليبيا

DOI:

https://doi.org/10.59743/jbs.v38i2.333

الكلمات المفتاحية:

الخلايا الجذعية، التهاب الأمعاء، التأثير المناعي، زرع الخلايا الجذعية

الملخص

تشمل التطورات الحديثة في علاج مرض التهاب الأمعاء (Inflammatory bowel disorder) علاجات طبية وجراحية وتنظيرية جديدة. ويعتبر العلاج بالخلايا الجذعية (Mesenchymal Stem Cells) في مراحله الأولى، على الرغم من أن العديد من الدراسات تشير إلى أن التأثير المناعي للعلاج بالخلايا الجذعية قد يقلل من الالتهاب وإصابة الأنسجة لدى مرضى داء الأمعاء الالتهابي. تناقش هذه الورقة التجارب السريرية العشوائية ودورها المحتمل على أن الزرع داخل الآفة للخلايا الجذعية الوسيطة الذاتية يمكن اعتباره نهجًا علاجيًا آمنًا وفعالًا لشفاء الناسور حول الشرج في مرضى كرون (Crohn's disease). لقد أجرينا بحثًا شاملاً لتحديد الدراسات التي تناولت دور العلاج بالخلايا الجذعية في مرض التهاب الأمعاء. تشير هذه الدراسات الى مخاوف تتعلق بالسلامة التطبيق منهجية الخلايا الجذعية الوسيطة منذ أن أبلغت العديد من التجارب السريرية عن تفاقم مرض التهاب الأمعاء بعد التسريب الوريدي للخلايا الجذعية الوسيطة.

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التنزيلات

منشور

2025-05-30

إصدار

القسم

الأحياء

كيفية الاقتباس

الخلايا الجذعية الوسيطة واستخدامها في مرض التهاب الأمعاء (الأشهب ن. ا. & والي خ. ن.). (2025). مجلة العلوم الأساسية, 38(2), 126-139. https://doi.org/10.59743/jbs.v38i2.333

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