Mesenchymal Stem Cells and Their Use in Inflammatory Bowel Disease
DOI:
https://doi.org/10.59743/jbs.v38i2.333Keywords:
stem cells, intestinal inflammation, immune effect, stem cell transplantationAbstract
Recent advances in the treatment of inflammatory bowel disease (IBD) include new medical, surgical, and endoscopic therapies. Mesenchymal stem cell therapy is still in its infancy, although several studies suggest that the immunomodulatory effect of stem cell therapy may reduce inflammation and tissue injury in patients with IBD. This paper discusses randomized clinical trials and their potential role in intralesional transplantation of mesenchymal stem cells. Autologous stem cell therapy may be considered a safe and effective therapeutic approach for healing perianal fistulas in Crohn's disease patients. We conducted a comprehensive literature search to identify studies examining the role of stem cell therapy in inflammatory bowel disease (IBD). These studies raise safety concerns regarding the systematic application of mesenchymal stem cells, since several clinical trials have reported worsening of inflammatory bowel disease following intravenous infusion of mesenchymal stem cells.
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References
L. Berkowitz et al., "Impact of cigarette smoking on the gastrointestinal tract inflammation: opposing effects in Crohn’s disease and ulcerative colitis," Frontiers in immunology, vol. 9, p. 74, 2018.
J. Askling et al., "Family history as a risk factor for colorectal cancer in inflammatory bowel disease," Gastroenterology, vol. 120, no. 6, pp. 1356-1362, 2001.
A. Y. Coqueiro, R. Raizel, A. Bonvini, J. Tirapegui, and M. M. Rogero, "Probiotics for inflammatory bowel diseases: a promising adjuvant treatment," International journal of food sciences and nutrition, vol. 70, no. 1, pp. 20-29, 2019.
D. Owczarek, T. Rodacki, R. Domagała-Rodacka, D. Cibor, and T. Mach, "Diet and nutritional factors in inflammatory bowel diseases," World journal of gastroenterology, vol. 22, no. 3, p. 895, 2016.
J. F. Rodemann, E. R. Dubberke, K. A. Reske, D. H. Seo, and C. D. Stone, "Incidence of Clostridium difficile infection in inflammatory bowel disease," Clinical Gastroenterology and Hepatology, vol. 5, no. 3, pp. 339-344, 2007.
C. R. Harrell, V. Djonov, and V. Volarevic, "The cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration," International journal of molecular sciences, vol. 22, no. 5, p. 2472, 2021.
H. Chaudhry et al., "Role of cytokines as a double-edged sword in sepsis," In vivo, vol. 27, no. 6, pp. 669-684, 2013.
T. Gramlich and R. E. Petras, "Pathology of inflammatory bowel disease," in Seminars in pediatric surgery, 2007, vol. 16, no. 3: Elsevier, pp. 154-163.
R. Rahimi, S. Nikfar, A. Rezaie, and M. Abdollahi, "Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis," Reproductive toxicology, vol. 25, no. 2, pp. 271-275, 2008.
Y. Qi, J. Ma, S. Li, and W. Liu, "Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes," Stem cell research & therapy, vol. 10, no. 1, pp. 1-13, 2019.
J. Kang et al., "Systematic exposition of mesenchymal stem cell for inflammatory bowel disease and its associated colorectal cancer," BioMed research international, vol. 2018, 2018.
L.-l. Qi, Z.-y. Fan, H.-g. Mao, and J.-b. Wang, "The Therapeutic Efficacy of Adipose Tissue-Derived Mesenchymal Stem Cell Conditioned Medium on Experimental Colitis Was Improved by the Serum From Colitis Rats," (in English), Frontiers in Bioengineering and Biotechnology, Original Research vol. 9, 2021-September-17 2021, doi: 10.3389/fbioe.2021.694908.
C. R. Harrell, C. Fellabaum, N. Jovicic, V. Djonov, N. Arsenijevic, and V. Volarevic, "Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome," Cells, vol. 8, no. 5, p. 467, 2019.
C. R. Harrell, N. Jovicic, V. Djonov, N. Arsenijevic, and V. Volarevic, "Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases," Cells, vol. 8, no. 12, p. 1605, 2019.
M. Gazdic, V. Volarevic, N. Arsenijevic, and M. Stojkovic, "Mesenchymal stem cells: a friend or foe in immune-mediated diseases," Stem Cell Reviews and Reports, vol. 11, no. 2, pp. 280-287, 2015.
A. K. S. Al-Maawali, P. Nguyen, and P. T. Phang, "Modern treatments and stem cell therapies for perianal Crohn’s fistulas," Canadian Journal of Gastroenterology and Hepatology, vol. 2016, 2016.
T. Otonkoski, G. M. Beattie, J. S. Rubin, A. D. Lopez, A. Baird, and A. Hayek, "Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells," Diabetes, vol. 43, no. 7, pp. 947-953, 1994.
L. Ferrer et al., "Treatment of perianal fistulas with human embryonic stem cell-derived mesenchymal stem cells: a canine model of human fistulizing Crohn's disease," Regenerative medicine, vol. 11, no. 1, pp. 33-43, 2016.
B. S. Markovic et al., "Molecular and cellular mechanisms involved in mesenchymal stem cell-based therapy of inflammatory bowel diseases," Stem Cell Reviews and Reports, vol. 14, no. 2, pp. 153-165, 2018.
C. J. Hawkey and D. W. Hommes, "Is stem cell therapy ready for prime time in treatment of inflammatory bowel diseases?," Gastroenterology, vol. 152, no. 2, pp. 389-397. e2, 2017.
Y. Cao, Z. Ding, C. Han, H. Shi, L. Cui, and R. Lin, "Efficacy of mesenchymal stromal cells for fistula treatment of Crohn’s disease: a systematic review and meta-analysis," Digestive Diseases and Sciences, vol. 62, no. 4, pp. 851-860, 2017.
G. Ferrari, B. D. Cook, V. Terushkin, G. Pintucci, and P. Mignatti, "Transforming growth factor‐beta 1 (TGF‐β1) induces angiogenesis through vascular endothelial growth factor (VEGF)‐mediated apoptosis," Journal of cellular physiology, vol. 219, no. 2, pp. 449-458, 2009.
M. Mebarki, C. Abadie, J. Larghero, and A. Cras, "Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products," Stem Cell Research & Therapy, vol. 12, no. 1, pp. 1-10, 2021.
C. R. Harrell et al., "Mesenchymal stem cell-based therapy of inflammatory lung diseases: current understanding and future perspectives," Stem cells international, vol. 2019, 2019.
M. Carvello, A. Lightner, T. Yamamoto, P. G. Kotze, and A. Spinelli, "Mesenchymal stem cells for perianal Crohn’s disease," Cells, vol. 8, no. 7, p. 764, 2019.
M. B. Murphy, K. Moncivais, and A. I. Caplan, "Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine," Experimental & molecular medicine, vol. 45, no. 11, pp. e54-e54, 2013.
A. Franzke, "The role of G-CSF in adaptive immunity," Cytokine & growth factor reviews, vol. 17, no. 4, pp. 235-244, 2006.
A. K. Berglund, L. A. Fortier, D. F. Antczak, and L. V. Schnabel, "Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells," Stem cell research & therapy, vol. 8, no. 1, pp. 1-7, 2017.
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