SYNTHESIS AND CHARACTERIZATION OF SOME QUINOXALINE DERIVATIVES AND THE STUDY OF BIOLOGICAL ACTIVITIES

المؤلفون

  • Khalifa A Alfallous Chemistry Department, Faculty of Science, Alasmarya Islamic University , Zliten-Libya

DOI:

https://doi.org/10.59743/jbs.v29i.69

الكلمات المفتاحية:

Quinoxaline derivatives، Organic synthesis and Biological activity

الملخص

In continuation of our endeavor towards the development of potent and effective anticancer and antimicrobial agents. A certain  Quinoxaline derivatives have been prepared, which have several pharmaceutical applications.  Quinoxaline derivatives are benzoheterocycles, quinoxaline-2, 3-diones. Some of quinoxaline compounds are synthesized and characterized such as 6,7-dichloroquinoxaline-2,3-dione and 6,7-dimethylquinoxaline-2,3-dione . Biological activity results were satisfactory.

المراجع

Reviews: A.E.A. Porter, in: A.R. Katritzky, C.W. Rees (Eds.), Comprehensive Heterocyclic Chemistry, vol. 3, part 2B, Pergamon, Oxford, 1984, p. 157;

N. Sato, vol. 6, in: A.R. Katritzky, C.W. Rees, E.F.V. Scriven (Eds.), Comprehensive Heterocyclic Chemistry II, vol. 6, Pergamon, Oxford, 1996, p. 233;

G. Sakata, K. Makino, Y. Kurasama, Heterocycles 27 (1988) 2481;

G.W.H. Cheeseman, E.S.G. Werstiuk, Adv. Heterocycl. Chem. 22 (1978) 367.

L.E. Seitz, W.J. Suling, R.C. Reynolds, J. Med. Chem. 45 (2002) 5604;

A. Gazit, H. App, G. McMahon, A. Chen, A. Levitzki, F.D. Bohmer, J. Med. Chem. 39 (1996) 2170;

A. Monge, J.A. Palop, J.C. Del Castillo, J.M. Caldero, J. Roca, G. Romero, J. Del Rio, B. Lasheras, J. Med. Chem. 36 (1993) 2745;

K. Toshima, R. Takano, T. Ozawa, S. Matsumara, Chem. Commun. (2002) 212.

Z. Wu, N.J. Ede, Tetrahedron Lett. 42 (2001) 8115;

J. Lee, W.V. Murray, R.A. Rivero, J. Org. Chem. 62 (1997) 3874;

R.J. Holland, I.R. Hardcastle, M. Jarman, Tetrahedron Lett. 43 (2002) 6435;

V. Krchnak, J. Smith, J. Vagner, Tetrahedron Lett. 41 (2000) 2835;

T. Uxey, P. Tempest, C. Hulme, Tetrahedron Lett. 43 (2002) 1637;

F. Zaragoza, H. Stephensen, J. Org. Chem. 64 (1999) 2555.

E.D. Brock, D.M. Lewis, T.I. Yousaf, H.H. Harper, The Proctor and Gamble Company, WO 9951688, 1999;

N.D. Sonawane, D.W. Rangnekar, J. Heterocycl. Chem. 39 (2002) 303;

A. Katoh, T. Yoshida, J. Ohkando, Heterocycles 52 (2000) 911.

S. Dailey, J.W. Feast, R.J. Peace, I.C. Sage, S. Till, E.L. Wood, J. Mater. Chem. 11 (2001) 2238;

D. O’Brien, M.S. Weaver, D.G. Lidzey, D.D.C. Bradley, Appl. Phys. Lett. 69 (1996) 881.

T. Mizuno, W.-H. Wei, L.R. Eller, J.L. Sessler, J. Am. Chem. Soc. 124 (2002) 1134;

A.H.M. Elwahy, Tetrahedron 56 (2000) 897.

J.C. Crossley, L.A. Johnston, Chem. Commun. (2002) 1122.

Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. Synthesis of new quinoxaline-2-Carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents. J. Med. Chem. 2005, 48, 2019–2025.

Ali, M.M.; Ismail, M.M.F.; El-Gaby, M.S.; Ammar, Y.A. Synthesis and antimicrobial activities of some novelquinoxalinone derivatives. Molecules 2000, 5, 864–873.

Wadavrao, S.B.; Ghogare, R.S.; Narsaiah, A.V. A simple and efficient protocol for the synthesis of quinoxalines catalyzed by pyridine. Org. Commun. 2013, 6, 23–30.

Aravind, K.; Ganesh, A.; Ashok, D. Microwave assisted synthesis, characterization and antibacterial activity of quinoxaline derivatives. J. Chem. Pharm. Res. 2013, 5, 48–52.

Sajjadifar, S.; Nezhad, E.R. Qinoxaline III. synthesis of quinoxaline derivatives over highly efficient and reusable bronsted acidic ionic liquids. Int. J. ChemTech Res. 2013, 5, 2041–2050.

Thomas, K.R.J.; Velusamy, M.; Lin, J.T.; Chuen, C.H.; Tao, Y.T. Chromophore-labeled qquinoxaline derivatives as efficient electroluminescent materials. Chem. Mater. 2005, 17, 1860–1866.

Toshima, K.; Takano, R.; Ozawa, T.; Matsumara, S. Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents. Chem. Commun. 2002, 3, 212–213.

Dailey, S.; Feast, W.J.; Peace, R.J.; Sage, I.C.; Till, S.; Wood, E.L. Synthesis and device characterization of side-chain polymer electron transport materials for organic semiconducting applications. J. Mater. Chem. 2001, 11, 2238–2243.

Kumar, A.; Kumar, S.; Saxena, A.; De, A.; Mozumdar, S. Ni-nanoparticles: An efficient catalyst for the synthesis of quinoxalines. Catal. Commun. 2008, 9, 778–784.

Sessler, J.L.; Maeda, H.; Mizuno, T.; Lynch, V.M.; Furuta, H. Quinoxaline-oligopyrroles: Improvedpyrrole-based anion receptors. Chem. Commun. 2002, 21, 862–863.

Wagle, S.; Adhikari. A.V.; Kumari, N.S. Ind. J. Chem. 2008, 47, 439–448.

Hong, Y.S.; Kim, H.M.; Park, Y.T.; Kirn, H.S. Bull. Korean Chem. Soc. 2000, 21, 133.

Ali, M.M.; Ismail, M.M.F.; Elgamy, M.S.A.; Zahran, M.A.; Ammar. Molecules 2000, 5, 864–873.

Dubey, P.K.; Naidu, A.; Vayas, S.; Vineel, B.G. Ind. J. Chem. 2005, 44B, 573–576.

W.L.F Armarego, D.D. Perrin, Purification of Laboratory Chemicals, fourth ed., Butterworth-Heinemann, Oxford, U.K., 2000.

W.A. Bauer, W.M. Kirby, C. Sherris, M. Turck, Am. J. Clin. Pathol. 45 (1966) 493.

H. Thakuria, G. Das, J. Chem. Sci. 118 (2006) 425.

K.F. Konidaris, G.S. Papaefstathiou, G. Aromi, S.J. Teat, E. Manessi-Zoupa, A. Escuer, S.P. Perlepes, Polyhedron 28 (2009) 1646.

H. Ertepinarl, Y. Gok, O. Geban, S. Ozden, Eur. J. Med. Chem. 30 (1995) 171.

A. Khalafi-Nezhad, M.N. Soltani Rad, H. Mohalbatkar, Z. Asrari, B. Hemmateenejad, Bioorg. Med. Chem. 13 (2005) 1931.

F. A. Peacock, P. J. Sadler Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents. Chem. Asian. J. 3 (2008) 1890–1899.

التنزيلات

منشور

2016-12-31

إصدار

القسم

مقالات

كيفية الاقتباس

SYNTHESIS AND CHARACTERIZATION OF SOME QUINOXALINE DERIVATIVES AND THE STUDY OF BIOLOGICAL ACTIVITIES (K. A. Alfallous). (2016). مجلة العلوم الأساسية, 29, 113-121. https://doi.org/10.59743/jbs.v29i.69

المؤلفات المشابهة

1-10 من 20

يمكنك أيضاً إبدأ بحثاً متقدماً عن المشابهات لهذا المؤلَّف.