Assessment of Hematological and Biochemical Indicators in Relation to Thyroid Function in Hemodialysis Patients in Al Khums City, Libya

Amnnah A Ihreebish; younis Muftah Al-Zaidi; Fadia A. Abdulsadiq

doi:10.59743/

Authors

Amnnah A. Ihreebish Department of Biology, Faculty of Science, El-Mergib University, Alkhums, Libya.
Younis Muftah Al-Zaidi Department of Zoology, Faculty of Education, El-Mergib University, Alkhums, Libya.
Fadia A. Abdulsadiq Department of Biology, Faculty of Science, El-Mergib University, Alkhums, Libya.

DOI:

https://doi.org/10.59743/

Keywords:

Biochemical parameters , Blood parameters, Chronic kidney disease, Thyroid hormones, Dialysis

Abstract

Abstract

Chronic kidney disease (CKD) is a major global health problem often accompanied by disturbances in calcium–phosphorus balance and dysregulation of parathyroid hormone (PTH). Secondary hyperparathyroidism is common in hemodialysis patients, contributing to bone disorders and vascular calcifications. This case–control study, conducted at Al Khums Kidney Hospital, Libya (July–December 2024), included 150 participants: 100 hemodialysis patients (50 males, 50 females) and 50 healthy controls (25 males, 25 females). Hematological parameters (HGB, RBC) and biochemical indicators (Urea, Creatinine, TSH, T3, T4) were measured using standard laboratory methods. Patients showed significantly higher Creatinine (9.55 ± 2.55mg/dL), Urea (148.88 ± 34.61mg/dL) and TSH (3.56 ± 0.62 μIU/mL), and lower T3 (0.96 ± 0.19 ng/ml), T4(6.56 ± 0.62 μg/dl) and HGB (10.92 ± 1.87 g/dL) compared to controls. Pearson correlation analysis revealed significant negative associations between Urea and T3, Creatinine and T3, as well as between HGB and both Urea and Creatinine. In contrast, significant positive associations were observed between Urea and Creatinine, RBC and T3, and Urea and TSH. These findings underscore the importance of regular monitoring of thyroid function and hematological parameters in hemodialysis patients to mitigate potential complications.

Keywords: Biochemical indicators, Chronic Kidney Disease, Hematological parameters, Hemodialysis, Thyroid Hormones.

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Author Biographies

Amnnah A. Ihreebish, Department of Biology, Faculty of Science, El-Mergib University, Alkhums, Libya.

Department of Biology, Faculty of Science, El-Mergib University, Alkhums, Libya.
Younis Muftah Al-Zaidi, Department of Zoology, Faculty of Education, El-Mergib University, Alkhums, Libya.

Department of Zoology, Faculty of Education, El-Mergib University, Alkhums, Libya.

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