Evaluation The Effect of Natural Phytotherapy on Level of Leptin Hormone in Serum With Chronic Periodontitis
DOI:
https://doi.org/10.59743/jaf.v8i1.348Keywords:
Leptin, IL-6, E. Coli, Moringa oleifera, periodontal inflamationAbstract
For a considerable amount of time, periodontal diseases have been recognized as serious health issues in various populations. It refers to a class of locally acquired microbially generated infections that affect the gingiva and the tissues that support the teeth. The two most common kinds of periodontal disorders are gingivitis and chronic periodontitis. It is acknowledged that the primary causative factor for the development and advancement of periodontitis is bacterial plaque. When untreated, chronic periodontitis begins as an inflammatory illness of the gingiva and can eventually spread to other sections of the periodontal attachment mechanism, resulting in damage and collapse. Natural agents with antibacterial and anti-inflammatory properties may be able to manage inflammatory illnesses like periodontitis. Natural plant chemicals have the capacity to regulate the immune system's inflammatory response.
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Kah Yan How, Keang Peng Song and Kok Gan Chan. Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Front Microbiol. 2016; 7: 53.
Pihlstrom BL, Michalowicz BS and Johnson NW. Periodontal diseases. Lancet 2005; 366: 1809–1820.
Mysak J, Podzimek S, Sommerova P, Lyuya-Mi Y, Bartova J, Janatova T et al., Porphyromonas gingivalis: Major periodontopathic pathogen overview. J Immunol Res 2014; 2014: 476068.
Gorąca A, Huk-Kolega H, Kleniewska P, Piechota-Polańczyk A and Skibska B. Effects of lipoic acid on spleen oxidative stress after LPS administration. Pharmacol Rep 2013; 65: 179–186.
Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, et al., Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J Periodontal Res 2009: 44: 21–27.
Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res 2010; 89: 1349– 1363.
Fonseca JE, Santos MJ and Canhao H. Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009: 8: 538–542.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372: 425–432.
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR and Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998; 394: 897–901.
Groschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, Tamguney G, et al., Identification of leptin in human saliva. J Clin Endocrinol Metab. 2001; 86: 5234–5239.
Karthikeyan BV and Pradeep AR. Leptin levels in gingival crevicular fluid in periodontal health and disease.J Periodontal Res. 2007; 42: 300–304.
Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: potential application in the prevention and treatment of oral diseases. Evid-Based Compl. AlT. 2011; 2011: 15.
Bose CK. Possible role of Moringa Oleifera Lam. Root in epithelial ovarian cancer. MED Gen MED. 2007; 9: 26.
Farooq F, Rai M, Tiwari A, Khan AA and Farooq S . Medicinal properties of Moringa oleifera: An overview of promising healer. J of Medicinal Plants Research. 2012; 6: 4368-4374.
Khalafalla MM, Abdellatef E, Dafalla MM, Nassrallah AA, Aboul-Enein KM, Lightfoot DA, et al., Active principle from Moringa oleifera Lamleaves effective against two leukemias and a hepatocarcinoma. Afr. J. Biotechnol. 2010; 9: 8467-8471.
Singh N and Gilca M. Herbal Medicine: Science embraces tradition: A new insight into ancient Ayurveda. Lambert Academic Publishing AGandCo KG Dudweiler Landstr 99,66123. Saarbrucken, Germany: ISBN 978-3-8383-2145-5.
Cowan MM. Plant products as antimicrobial agents. Clin. Microbiol. Rev. 1999; 12: 564–582.
Sinha M, Das DK, Bhattacharya S, Majumdar S and Dey S. Leaf extract of Moringa oleifera prevents lionizing radiation-induced oxidative stress in mice. J MED food. 2011; 14: 1167-1172.
Mukunzi D, Nsor-Atindana J, Zhang XM, Gahungu A, Karangwa E and Mukamurezi G. Comparison of volatile profile of Moringa oleifera leaves from Rwanda and China using HS-SPME. Pak J Nutr 2011; 10: 602-608.
Tiloke C, Phulukdaree A and Chuturgoon AA. The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC complementary and alternative medicine. 2013; 13: 226.
Johnson RB and Serio FG. Leptin within healthy and diseased human gingiva. J Periodontol. 2001; 72: 1254–1257.
Karthikeyan BV and Pradeep AR. Gingival crevicular fluid and serum leptin :their relationship to periodontal health and disease. J Clin Periodontal 2007; 34: 467-472.
Monea A, Gruber R, Elod N , Bereşescu G , Moldovan C and Monea M. Saliva and serum of TNF-α and IL- 6 in a sample of Romanian adult subjects with type 2 diabetes mellitus and periodontal disease. European Scientific Journal , 2014 ; 10: 1857 -7881 .
Choi EY, Jin JY, Choi JI, Choi IS and Kim SJ. DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. Br J Nutr, 2014; 111: 1221–1230.
Noh MK, Jung M, Kim SH, Lee SR, Park KH, Kim DH, et al., Assessment of IL 6, IL 8 and TNF α levels in the gingival tissue of patients with periodontitis. Expermental And Therapeutic Medicine, 2013; 6: 847-851.
Takashiba S, Naruishi K and Murayama Y. Perspective of cytokine regulation for periodontal treatment: fibroblast biology. Journal of periodontology ,2003; 74: 103-110.
.Raghavendra NM, Pradeep AR, Kathariya R, Sharma A, Rao NS and Naik SB. Effect of non surgical periodontal therapy on gingival crevicular fluid and serum visfatin concentration in periodontal health and disease. Disease Markers, 2012; 32: 383–388 .
Kardesler L, Buduneli N, Cetinkalp S & Kinane D F ."Adipokines and Inflammatory Mediators after Initial Periodontal Treatment in Patients with Type 2 Diabetes and Chronic Periodontitis," Journal of Periodontology, 2010; 81: 24-33.
Kocak E, Sağlam, Kayış SA et al. Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial, 2016; 31: 343-353.
Shi D, Liu YY, Li W, Zhang X, Sun XJ, Li Xu, Zhang L, Chen ZB, and Meng HN. Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis. Chin Med J, 2015; 128: 528–532.
Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Sugita N and Yoshie H. The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. J Periodontol. 2010; 81: 1118–1123.
Bansal S, Rastogi S and Meenakshi Bajpai M. Mechanical, chemical and herbal aspects of periodontitis.IJPSR. 2012; 3: 1260–1267.
Chainy GB, Manna SK, Chaturvedi MM and Aggarwal BB. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis.Oncogene. 2000; 19: 2943–2950.
Swathi K, Savita AM, Pallavi Nanaiah. K, Abhilash N, Vaijinathrao SS and Abdul H. ANTIMICROBIAL EFFECTS OF PHYLLANTHUS EMBLICA EXTRACT AND MORINGA OLIEFERA EXTRACT ON SPECIFIC PERIODONTOPATHOGENS - AN IN VITRO STUDY, International Jornal of Analytical, pharmaceutical and biomedical sciences. 2016; 5: 2278-0246.
Anwar F, Ashraf M, Latif S and Gilani AH. Moringa Oleifera: A Food Plant with Multiple Medicinal Uses.Phytother. Res. 2007; 21: 17–25.
Nagasheree R, Latha R and Karthikeyan V. Effect of leaves of Moringa Oleifera on biochemical and physiological parameters in rats. Journal of natural remedies . 2011; 11: 1.
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