Prevalence of Blood-Borne Viruses in Hemodialysis Patients in Zliten, Libya
DOI:
https://doi.org/10.59743/jaf.v7i2.331Keywords:
HBV, HCV, Hemodialysis, HIV, OBI, PrevalenceAbstract
Patients on hemodialysis (HD) are at high risk of infection with human immunodeficiency virus (HIV), overt hepatitis B virus (HBV), occult HBV (OBI) and hepatitis C virus (HCV). We aimed to assess the prevalence of HBV, antibody to HBV core antigen (anti-HBc), OBI, HCV and HIV among patients on HD attending HD unit of Zliten Teaching Hospital. Eighty HD cases were serologically screened for HBV surface antigen (HBsAg), antibody to HCV (anti-HCV) and antibody to human immunodeficiency virus (anti-HIV). Negative HBsAg samples were further evaluated for Anti-HBc and antibody to HBV surface antigen (anti-HBs). Positive anti-HBc samples were then evaluated for HBV DNA by using real time PCR. The prevalence of HBsAg, anti-HBc, OBI, anti-HCV and anti-HIV among HD cases were 2.5%, 25.6%, 0%, 41.3% and 0% respectively. Positivity of anti-HBc had significant relationship with positivity of anti-HCV (P = 0 .000). We concluded that prevalence of HCV in HD patients was greatly higher than that of HBVand None of the cases had OBI or HIV infection.
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Abou Rached, A., El Khoury, L., El Imad, T., Geara, A. S., Jreijiry, J., & Ammar, W. (2016). Incidence and prevalence of hepatitis B and hepatitis C viruses in hemodialysis patients in Lebanon. World J Nephrol, 5(1), 101-107. https://doi.org/10.5527/wjn.v5.i1.101
Aghakhani, A., Banifazl, M., Velayati, A. A., Eslamifar, A., & Ramezani, A. (2012). Occult Hepatitis B Virus Infection in Hemodialysis Patients: A Concept for Consideration. Therapeutic Apheresis and Dialysis, 16(4), 328-333. https://doi.org/https://doi.org/10.1111/j.1744-9987.2012.01072.x
Alashek, W. A., McIntyre, C. W., & Taal, M. W. (2012). Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors. BMC infectious diseases, 12(1), 265. https://doi.org/10.1186/1471-2334-12-265
Albakosh, A. M., Alshwin F. O., Arshah T. M. (2017). The prevalence of anti-HBc antibody among HBsAg-negative Libyan blood donors and its association with HBV DNA in the serum. Journal of Basic Sciences, 30;30, 76-82.
Ali, M. S., Moftah, H., & Moftah, S. (2017). Hepatitis B Virus and Hepatitis C Virus in Hemodialysis Patients: A Prevalence Study from Dialysis Centers in El-Beyda and Almarj- Libya. Asian Journal of Biology, 2, 1-5. https://doi.org/10.9734/AJOB/2017/31912
Alkhalifah, R. H., Alhaddad, M. J., Alhashem, A. T., Alwesaibi, H., AlKhalaf, A. A., Saad, A. A., Almattar, M., Alkhalaf, M. A., Alramadhan, H., & Albaggal, M. (2023). Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Hemodialysis Patients at Kano Kidney Center. Cureus, 15(7).
Arababadi, M. K., Hassanshahi, G., & Yousefi, H. (2009). HBV-DNA in hemodialysis patients infected by HCV. Saudi J Kidney Dis Transpl, 20(3), 398-401.
Bernieh, B. (2015). Viral hepatitis in hemodialysis: An update. J Transl Int Med, 3(3), 93-105. https://doi.org/10.1515/jtim-2015-0018
Cordeiro, V. M., Martins, B. C. T., Teles, S. A., Martins, R. M. B., Cruvinel, K. P. S., Matos, M. A. D., Luz, J. A., Barreto, R., Teles, J. A., Santos, N. C., Caetano, K. A. A., & Carneiro, M. (2018). Decline in hepatitis B and C prevalence among hemodialysis patients in Tocantins, Northern Brazil. Rev Inst Med Trop Sao Paulo, 60, e36. https://doi.org/10.1590/s1678-9946201860036
Daw, M. A., Shabash, A., El-Bouzedi, A., & Dau, A. A. (2014). Seroprevalence of HBV, HCV & HIV co-infection and risk factors analysis in Tripoli-Libya. PLoS One, 9(6), e98793. https://doi.org/10.1371/journal.pone.0098793
Di Stefano, M., Volpe, A., Stallone, G., Tartaglia, L., Prato, R., Martinelli, D., Pastore, G., Gesualdo, L., & Fiore, J. R. (2009). Occult HBV infection in hemodialysis setting is marked by presence of isolated antibodies to HBcAg and HCV. J Nephrol, 22(3), 381-386.
El-Ottol, A. E.-k. Y., Elmanama, A. A., & Ayesh, B. M. (2010). Prevalence and risk factors of hepatitis B and C viruses among haemodialysis patients in Gaza strip, Palestine. Virology Journal, 7(1), 210. https://doi.org/10.1186/1743-422X-7-210
Elbahrawy, A., Alaboudy, A., El Moghazy, W., Elwassief, A., Alashker, A., & Abdallah, A. M. (2015). Occult hepatitis B virus infection in Egypt. World J Hepatol, 7(12), 1671-1678. https://doi.org/10.4254/wjh.v7.i12.1671
Fabrizi, F., Messa, P. G., Lunghi, G., Aucella, F., Bisegna, S., Mangano, S., Villa, M., Barbisoni, F., Rusconi, E., & Martin, P. (2005). Occult hepatitis B virus infection in dialysis patients: a multicentre survey. Aliment Pharmacol Ther, 21(11), 1341-1347. https://doi.org/10.1111/j.1365-2036.2005.02501.x
Helaly, G. F., El Ghazzawi, E. F., Shawky, S. M., & Farag, F. M. (2015). Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt. J Infect Public Health, 8(6), 562-569. https://doi.org/10.1016/j.jiph.2015.04.019
Joukar, F., Besharati, S., Mirpour, H., & Mansour-Ghanaei, F. (2011). Hepatitis C and hepatitis B seroprevalence and associated risk factors in hemodialysis patients in Guilan province, north of Iran: HCV and HBV seroprevalence in hemodialysis patients. Hepat Mon, 11(3), 178-181.
Kansay, S., Sekhon, J., & Rana, S. (2019). Seroprevalence of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among hemodialysis patients in a Tertiary Care Teaching Hospital in a developing country. Indian J Sex Transm Dis AIDS, 40(2), 120-125. https://doi.org/10.4103/ijstd.IJSTD_53_17
Lioussfi, Z., Errami, Z., Radoui, A., Rhou, H., Ezzaitouni, F., Ouzeddoun, N., Bayahia, R., & Benamar, L. (2014). Viral hepatitis C and B among dialysis patients at the Rabat University Hospital: prevalence and risk factors. Saudi J Kidney Dis Transpl, 25(3), 672-679. https://doi.org/10.4103/1319-2442.132236
Lodhi, A., Sajjad, A., Mehmood, K., Lodhi, A., Rizwan, S., Ubaid, A., Baloch, K., Ahmed, S., Ud Din, M., & Mehmood, Z. (2019). Profile and predictors of hepatitis and HIV infection in patients on hemodialysis of Quetta, Pakistan. Drug Discov Ther, 13(5), 274-279. https://doi.org/10.5582/ddt.2019.01044
Luma, H. N., Halle, M. P., Eloumou, S., Azingala, F., Kamdem, F., Donfack-Sontsa, O., & Ashuntantang, G. (2017). Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses among haemodialysis patients in two newly opened centres in Cameroon. Pan Afr Med J, 27, 235. https://doi.org/10.11604/pamj.2017.27.235.13121
Mahupe, P., Molefe-Baikai, O. J., Saleshando, G., & Rwegerera, G. M. (2021). Prevalence and risk factors for hepatitis b and c among end-stage renal disease patients on hemodialysis in Gaborone, Botswana. Niger J Clin Pract, 24(1), 81-88. https://doi.org/10.4103/njcp.njcp_464_19
Masoodi, I., Singh, C., Wani, I. A., Wani, M. M., Ahmed, T. I., & Sheikh, R. Y. (2019). Sero conversion of viral hepatitis among end stage renal disease patients on hemodialysis in Kashmir: Results of a prospective study. Open Access Macedonian Journal of Medical Sciences, 7(4), 587.
Mina, P., Georgiadou, S. P., Rizos, C., Dalekos, G. N., & Rigopoulou, E. I. (2010). Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece. World J Gastroenterol, 16(2), 225-231. https://doi.org/10.3748/wjg.v16.i2.225
Mittal, G., Gupta, P., Thakuria, B., Mukhiya, G. K., & Mittal, M. (2013). Profile of hepatitis B virus, hepatitis C virus, hepatitis d virus and human immunodeficiency virus infections in hemodialysis patients of a tertiary care hospital in Uttarakhand. Journal of Clinical and Experimental Hepatology, 3(1), 24-28.
Musa, M. D., & Ateya, H. K. (2020). Prevalence of overt and occult hepatitis B virus infections among 135 haemodialysis patients attending a haemodialysis centre at Al-Nasiriyah city, Iraq. Iran J Microbiol, 12(5), 475-482. https://doi.org/10.18502/ijm.v12i5.4610
Raina, D., Rawat, N., & Pandita, A. K. (2022). Prevalence of Hepatitis B and Hepatitis C in Patients undergoing hemodialysis at a teaching hospital in Uttarakhand. J Family Med Prim Care, 11(4), 1348-1353. https://doi.org/10.4103/jfmpc.jfmpc_1017_21
Ramezani, A., Aghasadeghi, M. R., Ahmadi, F., Razeghi, E., Eslamifar, A., Banifazl, M., Sofian, M., Bahramali, G., Hekmat, S., & Aghakhani, A. (2015). Isolated anti-hbc and occult HBV infection in dialysis patients. Nephro-urology monthly, 7(1).
Roushan, M. R. H., Farokhtabar, S., Bayani, M., & Siadati, S. (2016). Epidemiological aspects of hepatitis B and C and human immunodeficiency viruses among hemodialysis patients in Mazandaran Province, Iran. Nephro-urology monthly, 8(3).
Shamsdin, S. A., Fatahi, M. R., Ansari, A. R., & Safarpour, A. R. (2022). Prevalence of HBV, HCV, and HIV Infections among Patients Undergoing Hemodialysis in Fasa, Iran: A Six-Year Follow-up Study. Middle East J Dig Dis, 14(3), 317-322. https://doi.org/10.34172/mejdd.2022.289
Telaku, S., Fejza, H., Elezi, Y., & Bicaj, T. (2009). Hepatitis B and C in dialysis units in Kosova. Virology Journal, 6(1), 72. https://doi.org/10.1186/1743-422X-6-72
Yoo, J. H., Hwang, S. G., Yang, D. H., Son, M. S., Kwon, C. I., Ko, K. H., Hong, S. P., Park, P. W., & Rim, K. S. (2013). Prevalence of occult hepatitis B virus infection in hemodialysis patients. Korean J Gastroenterol, 61(4), 209-214. https://doi.org/10.4166/kjg.2013.61.4.209
Zahedi, M. J., Darvish Moghaddam, S., Alavian, S. M., & Dalili, M. (2012). Seroprevalence of Hepatitis Viruses B, C, D and HIV Infection Among Hemodialysis Patients in Kerman Province, South-East Iran. Hepat Mon, 12(5), 339-343. https://doi.org/10.5812/hepatmon.5969
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