The concept of Osteomyelitis and Inflammatory Bone Disorders: Histopathology, Diagnosis and management

Laila Mustafa     Abdelrahim

doi:10.59743/jaf.v9i1.617

Authors

Laila Mustafa Abdelrahim Collage of Dentistry and Oral Surgery, Alasmarya university, Zliten, Libya

DOI:

https://doi.org/10.59743/jaf.v9i1.617

Keywords:

Bone disease, Osteomyelitis, Histopathology, Treatment

Abstract

Inflammatory diseases of the jaw bone can encompass a variety of conditions, characterized by the presence of inflammation in the maxillary or mandibular bones. Osteomyelitis, a bacterial infection of the bone, is one of the most notable examples. The jawbone's complex anatomy, including its proximity to vital structures such as nerves and sinuses, means that inflammatory diseases can lead to significant complications. Early intervention is crucial for preventing irreversible damage and alleviating pain. As research continues, new horizons are emerging in understanding the mechanisms behind inflammatory diseases of the jaw bone. Advances in molecular biology and genetics are paving the way for targeted therapies and personalized medicine approaches. This paper aimed to categorized bone infections into. Meanwhile, a brief histopathological feature, radiographic appearance and treatment modality for each entity was provided.

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References

Almazrooa, S. A., & Woo, S. B. (2009). Bisphosphonate and nonbisphosphonate-associated osteonecrosis of the jaw: a review. The Journal of the American Dental Association, 140(7), 864-875 DOI: https://doi.org/10.14219/jada.archive.2009.0280

Andre CV, Khonsari RH, Ernenwein D, Goudot P, Ruhin B. Osteomyelitis of the jaws: a retrospective series of 40 patients. J Stomatol Oral Maxillofac Surg 2017;118:261-264. DOI: https://doi.org/10.1016/j.jormas.2017.04.007

Baltensperger, M., Grätz, K., Bruder, E., Lebeda, R., Makek, M., & Eyrich, G. (2004). Is primary chronic osteomyelitis a uniform disease? Proposal of a classification based on a retrospective analysis of patients treated in the past 30 years. Journal of Cranio-Maxillofacial Surgery, 32(1), 43-50. DOI: https://doi.org/10.1016/j.jcms.2003.07.008

Baltensperger M., Eyrich G. Osteomyelitis of the Jaws. In: Baltensperger M.M., Eyrich G.K.H., editors. Osteomyelitis of the Jaws. Springer; Berlin/Heidelberg, Germany: 2009. DOI: https://doi.org/10.1007/978-3-540-28766-7

Bagan, J. V., Hens-Aumente, E., Leopoldo-Rodado, M., Poveda-Roda, R., & Bagan, L. (2012). Bisphosphonate-related osteonecrosis of the jaws: study of the staging system in a series of clinical cases. Oral oncology, 48(8), 753-757.‏ DOI: https://doi.org/10.1016/j.oraloncology.2012.02.009

Baur, D. A., Altay, M. A., Flores-Hidalgo, A., Ort, Y., & Quereshy, F. A. (2015). Chronic osteomyelitis of the mandible: diagnosis and management—an institution's experience over 7 years. Journal of Oral and Maxillofacial Surgery, 73(4), 655-665.‏ DOI: https://doi.org/10.1016/j.joms.2014.10.017

Blum, I. R. (2002). Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. International journal of oral and maxillofacial surgery, 31(3), 309-317.‏ DOI: https://doi.org/10.1054/ijom.2002.0263

Bowe, D. D. C. (2011). The management of dry socket alveolar osteitis.‏

Carlson, E. R., & Basile, J. D. (2009). The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. Journal of Oral and Maxillofacial Surgery, 67(5), 85-95.‏ DOI: https://doi.org/10.1016/j.joms.2009.01.006

Chen, L., Li, T., Jing, W., Tang, W., Tian, W., Li, C., & Liu, L. (2013). Risk factors of recurrence and life-threatening complications for patients hospitalized with chronic suppurative osteomyelitis of the jaw. BMC Infectious Diseases, 13, 1-8.‏ DOI: https://doi.org/10.1186/1471-2334-13-313

Chow O, Wang R, Ku D, Huang W. Alveolar Osteitis: A Review of Current Concepts. J Oral Maxillofac Surg. 2020 Aug;78(8):1288-1296. DOI: https://doi.org/10.1016/j.joms.2020.03.026

Chronopoulos, A., Zarra, T., Ehrenfeld, M., & Otto, S. (2018). Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review. International dental journal, 68(1), 22-30. DOI: https://doi.org/10.1111/idj.12318

Conterno, L. O., & Turchi, M. D. (2013). Antibiotics for treating chronic osteomyelitis in adults. Cochrane database of systematic reviews, (9). DOI: https://doi.org/10.1002/14651858.CD004439.pub3

Daly B, Sharif MO, Newton T, Jones K, Worthington HV. Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev. 2012 Dec 12;12. DOI: https://doi.org/10.1002/14651858.CD006968.pub2

Dym H, Zeidan J. Microbiology of acute and chronic osteomyelitis and antibiotic treatment. Dent Clin North Am 2017;61:271-282. DOI: https://doi.org/10.1016/j.cden.2016.12.001

Erişen, M., Bayar, O. F., & Ak, G. (2014). Garre osteomyelitis: a case report. J Dent Fac Atatürk Univ, 9, 49-53.‏ DOI: https://doi.org/10.17567/dfd.52303

Haeffs TH, Scott CA, Campbell TH, Chen Y, August M. Acute and chronic suppurative osteomyelitis of the jaws: a 10-year review and assessment of treatment outcome. J Oral Maxillofac Surg 2018;76:2551-2558. DOI: https://doi.org/10.1016/j.joms.2018.05.040

Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011 Nov 01;84(9):1027-33.

Hinchy, N. V., Jayaprakash, V., Rossitto, R. A., Anders, P. L., Korff, K. C., Canallatos, P., & Sullivan, M. A. (2013). Osteonecrosis of the jaw–Prevention and treatment strategies for oral health professionals. Oral oncology, 49(9), 878-886.‏ DOI: https://doi.org/10.1016/j.oraloncology.2013.06.008

Holly, D., Jurkovic, R., & Mracna, J. (2009). Condensing osteitis in oral region. Bratislavske lekarske listy, 110(11), 713-715.‏

Jayasenthil, A., Aparna, P., & Balagopal, S. (2015). Non-surgical endodontic management of Garre's osteomyelitis: a case report. British Journal of Medicine and Medical Research, 9(3), 1-4. DOI: https://doi.org/10.9734/BJMMR/2015/17772

Jia, K., Li, T., & An, J. (2021). Is Operative Management Effective for Non-Bacterial Diffuse Sclerosing Osteomyelitis of the Mandible?. Journal of Oral and Maxillofacial Surgery, 79(11), 2292-2298.‏ DOI: https://doi.org/10.1016/j.joms.2021.06.024

Julien Saint Amand M., Sigaux N., Gleizal A., Bouletreau P., Breton P. Chronic Osteomyelitis of the Mandible: A Comparative Study of 10 Cases with Primary Chronic Osteomyelitis and 12 Cases with Secondary Chronic Osteomyelitis. J. Stomatol. Oral Maxillofac. Surg. 2017;118:342–348. DOI: https://doi.org/10.1016/j.jormas.2017.08.006

Kannan, S. K., Sandhya, G., & Selvarani, R. (2006). Periostitis ossificans (Garrè's osteomyelitis) radiographic study of two cases. International Journal of Paediatric Dentistry, 16(1), 59-64.‏ DOI: https://doi.org/10.1111/j.1365-263X.2006.00630.x

Kesting M.R., Thurmüller P., Ebsen M., Wolff K.-D. Severe Osteomyelitis Following Immediate Placement of a Dental Implant. Int. J. Oral Maxillofac. Implant. 2008;23:137–142.

Kodama, Y., Tanaka, R., Kurokawa, A., Ohnuki, H., Sultana, S., Hayashi, T., ... & Takagi, R. (2013). Severe destruction of the temporomandibular joint with complete resorption of the condyle associated with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(2), e128-e133.‏ DOI: https://doi.org/10.1016/j.oooo.2013.03.011

Koorbusch, G. F., Deatherage, J. R., & Curé, J. K. (2011). How can we diagnose and treat osteomyelitis of the jaws as early as possible?. Oral and Maxillofacial Surgery Clinics, 23(4), 557-567.‏ DOI: https://doi.org/10.1016/j.coms.2011.07.011

Lew, D. P., & Waldvogel, F. A. (2004). Osteomyelitis. The Lancet, 364(9431), 369-379.‏ DOI: https://doi.org/10.1016/S0140-6736(04)16727-5

Marí, A., Morla, A., Melero, M., Schiavone, R., & Rodríguez, J. (2014). Diffuse sclerosing osteomyelitis (DSO) of the mandible in SAPHO syndrome: a novel approach with anti-TNF therapy. Systematic review. Journal of Cranio-Maxillofacial Surgery, 42(8), 1990-1996.‏ DOI: https://doi.org/10.1016/j.jcms.2014.09.004

Monsour, P. A. J., & Dalton, J. B. (2010). Chronic recurrent multifocal osteomyelitis involving the mandible: case reports and review of the literature. Dentomaxillofacial Radiology, 39(3), 184-190.‏ DOI: https://doi.org/10.1259/dmfr/23060413

Omami G. The Moth-Eaten Mandible: Osteomyelitis. Ear, Nose & Throat Journal. 2023;102(8) DOI: https://doi.org/10.1177/01455613211014289

Owlia, F., Karbassi, M. H. A., Mirjalili, N., Zahir, S. T., Gholami, N., & Karimi, S. (2011). A localized sclerosing osteomyelitis at the periapex of a vital tooth: report of a misdiagnosis. Journal of dental research, dental clinics, dental prospects, 5(3), 102.‏

Prasad KC, Prasad SC, Mouli N, Agarwal S. Osteomyelitis in the head and neck. Acta Otolaryngol 2007;127:194-205. DOI: https://doi.org/10.1080/00016480600818054

Paterson DL. Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs). Clin Microbiol Infect 2000;6:460-463. DOI: https://doi.org/10.1046/j.1469-0691.2000.00107.x

Pedro R, José M, Ana D, João R, Eduardo G, Cátia S, António L, Tiago D, Irina X. Condensing osteitis in the diagnosis consultation at Egas Moniz University Clinic. Ann Med. 2019 May 28;51(Suppl 1):129. DOI: https://doi.org/10.1080/07853890.2018.1562738

Schmitt SK. Osteomyelitis. Infect Dis Clin North Am. 2017 Jun;31(2):325-338. DOI: https://doi.org/10.1016/j.idc.2017.01.010

Schuknecht, B., & Valavanis, A. (2003). Osteomyelitis of the mandible. Neuroimaging Clinics, 13(3), 605-618.‏ DOI: https://doi.org/10.1016/S1052-5149(03)00044-3

Suei Y., Taguchi A., Tanimoto K. Diagnosis and Classification of Mandibular Osteomyelitis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2005;100:207–214. DOI: https://doi.org/10.1016/j.tripleo.2004.11.006

Suma, R., Vinay, C., Shashikanth, M. C., & Reddy, V. S. (2007). Garre's sclerosing osteomyelitis. Journal of Indian Society of Pedodontics and Preventive Dentistry, 25(Supplement), S30-S33.‏ DOI: https://doi.org/10.4103/0970-4388.34744

Taberner-Vallverdú, M., Nazir, M., Sánchez-Garcés, M. Á., & Gay-Escoda, C. (2015). Efficacy of different methods used for dry socket management: A systematic review. Medicina oral, patologia oral y cirugia bucal, 20(5), e633.‏ DOI: https://doi.org/10.4317/medoral.20589

Uçkay I, Jugun K, Gamulin A, Wagener J, Hoffmeyer P, Lew D. Chronic osteomyelitis. Curr Infect Dis Rep. 2012 Oct;14(5):566-75. DOI: https://doi.org/10.1007/s11908-012-0286-0

Ueda N, Nakashima C, Aoki K, Shimotsuji H, Nakaue K, Yoshioka H, Kurokawa S, Imai Y, Kirita T. Does inflammatory dental disease affect the development of medication-related osteonecrosis of the jaw in patients using high-dose bone-modifying agents? Clin Oral Investig. 2021 May;25(5):3087-3093. doi: 10.1007/s00784-020-03632-7. Epub 2020 Oct 14. PMID: 33057886. DOI: https://doi.org/10.1007/s00784-020-03632-7

Woo, S. B., Hellstein, J. W., & Kalmar, J. R. (2006). Systematic review: bisphosphonates and osteonecrosis of the jaws. Annals of internal medicine, 144(10), 753-761.‏ DOI: https://doi.org/10.7326/0003-4819-144-10-200605160-00009